4EQJ
Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate RT-RH
Summary for 4EQJ
Entry DOI | 10.2210/pdb4eqj/pdb |
Related | 4EP2 4EP3 4EPJ 4EQ0 |
Descriptor | protease, tethered dimer, substrate RT-RH, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | hiv-1 protease, specificity design, drug design, protease inhibitors, aids, aspartyl protease, hydrolase, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 2 |
Total formula weight | 23534.66 |
Authors | Schiffer, C.A.,Mittal, S. (deposition date: 2012-04-19, release date: 2012-06-06, Last modification date: 2024-02-28) |
Primary citation | Alvizo, O.,Mittal, S.,Mayo, S.L.,Schiffer, C.A. Structural, kinetic, and thermodynamic studies of specificity designed HIV-1 protease. Protein Sci., 21:1029-1041, 2012 Cited by PubMed: 22549928DOI: 10.1002/pro.2086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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