4EQJ
Crystal Structure of inactive single chain variant of HIV-1 Protease in Complex with the substrate RT-RH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | protease, tethered dimer | polymer | 203 | 22169.2 | 1 | UniProt (P03369) Pfam (PF00077) | HIV-1 M:B_ARV2/SF2 (HIV-1) | |
| 2 | B (G) | substrate RT-RH | polymer | 8 | 900.9 | 1 | UniProt (Q9YV20) | Human immunodeficiency virus 1 | |
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | I (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | J, K (A, G) | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A: 1 - 99 (UniProt: P03369)
A: 101 - 199 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 497 | engineered mutation |
| Asn 25 | Asp 515 | engineered mutation |
| Leu 67 | Cys 557 | engineered mutation |
| Met 95 | Cys 585 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 100 | - | linker |
| Gly 100 | - | linker |
| Ser 100 | - | linker |
| Ser 100 | - | linker |
| Gly 100 | - | linker |
| Lys 107 | Gln 497 | engineered mutation |
| Asn 125 | Asp 515 | engineered mutation |
| Leu 167 | Cys 557 | engineered mutation |
| Met 195 | Cys 585 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 23070.2 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 464.5 | |
| All* | Total formula weight | 23534.7 |
