4EPH
CRYSTAL STRUCTURE OF RAT CARNITINE PALMITOYLTRANSFERASE 2 IN COMPLEX with CoA-site inhibitor
Summary for 4EPH
Entry DOI | 10.2210/pdb4eph/pdb |
Related | 2DEB 2FW3 2FYO 2H4T 2RCU 4EP9 |
Descriptor | Carnitine O-palmitoyltransferase 2, mitochondrial, 2-chloro-4-[({1-[(5-chloro-2-methoxyphenyl)sulfonyl]-4-methyl-2,3-dihydro-1H-indol-6-yl}carbonyl)amino]benzoic acid, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | transferase, acyltransferase, mitochondrial protein, coa, acylcarnitine, mitochondrial inner membrane, lipid transport, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Total number of polymer chains | 1 |
Total formula weight | 74393.86 |
Authors | Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. (deposition date: 2012-04-17, release date: 2013-04-17, Last modification date: 2023-09-13) |
Primary citation | Perspicace, S.,Rufer, A.C.,Thoma, R.,Mueller, F.,Hennig, M.,Ceccarelli, S.,Schulz-Gasch, T.,Seelig, J. Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein. FEBS Open Bio, 3:204-211, 2013 Cited by PubMed: 23772395DOI: 10.1016/j.fob.2013.04.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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