4EP9

CRYSTAL STRUCTURE OF RAT CARNITINE PALMITOYLTRANSFERASE 2 IN COMPLEX WITH CoA-site inhibitor

4EP9 の概要

• エントリーDOI: 10.2210/pdb4ep9/pdb
• 関連するPDBエントリー: 2DEB 2FW3 2FYO 2H4T 2RCU 4EPH
• 分子名称: Carnitine O-palmitoyltransferase 2, mitochondrial, 4-[({1-[(5-chloro-2-methoxyphenyl)sulfonyl]-4-methyl-2,3-dihydro-1H-indol-6-yl}carbonyl)amino]benzoic acid, PALMITIC ACID, ... (4 entities in total)
• 機能のキーワード: transferase, acyltransferase, mitochondrial protein, coa, acylcarnitine, mitochondrial inner membrane, lipid transport, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side : P18886
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 74323.47

構造登録者

Rufer, A.C.,Thoma, R.,Benz, J.,Stihle, M.,Gsell, B.,De Roo, E.,Banner, D.W.,Mueller, F.,Chomienne, O.,Hennig, M. (登録日: 2012-04-17, 公開日: 2013-04-17, 最終更新日: 2023-09-13)

• 主引用文献: Perspicace, S.,Rufer, A.C.,Thoma, R.,Mueller, F.,Hennig, M.,Ceccarelli, S.,Schulz-Gasch, T.,Seelig, J.; Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein.; FEBS Open Bio, 3:204-211, 2013; PubMed: 23772395; DOI: 10.1016/j.fob.2013.04.003

実験手法

X-RAY DIFFRACTION (2.03 Å)