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4EOX

X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor

Summary for 4EOX
Entry DOI10.2210/pdb4eox/pdb
DescriptorPeptide deformylase, NICKEL (II) ION, N-benzoyl-1-[(2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl]-L-prolinamide, ... (4 entities in total)
Functional Keywordsalpha-beta, peptide deformylase metal ion binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceStreptococcus pneumoniae
Total number of polymer chains1
Total formula weight23195.22
Authors
Ward, P.,Campobasso, N. (deposition date: 2012-04-16, release date: 2012-05-30, Last modification date: 2024-02-28)
Primary citationAxten, J.M.,Medina, J.R.,Blackledge, C.W.,Duquenne, C.,Grant, S.W.,Bobko, M.A.,Peng, T.,Miller, W.H.,Pinckney, T.,Gallagher, T.F.,Kulkarni, S.,Lewandowski, T.,Van Aller, G.S.,Zonis, R.,Ward, P.,Campobasso, N.
Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity.
Bioorg.Med.Chem.Lett., 22:4028-4032, 2012
Cited by
PubMed: 22579486
DOI: 10.1016/j.bmcl.2012.04.086
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.783 Å)
Structure validation

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