4EOX
X-ray Structure of Polypeptide Deformylase Bound to a Acylprolinamide inhibitor
Summary for 4EOX
Entry DOI | 10.2210/pdb4eox/pdb |
Descriptor | Peptide deformylase, NICKEL (II) ION, N-benzoyl-1-[(2R)-3-cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl]-L-prolinamide, ... (4 entities in total) |
Functional Keywords | alpha-beta, peptide deformylase metal ion binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Streptococcus pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 23195.22 |
Authors | Ward, P.,Campobasso, N. (deposition date: 2012-04-16, release date: 2012-05-30, Last modification date: 2024-02-28) |
Primary citation | Axten, J.M.,Medina, J.R.,Blackledge, C.W.,Duquenne, C.,Grant, S.W.,Bobko, M.A.,Peng, T.,Miller, W.H.,Pinckney, T.,Gallagher, T.F.,Kulkarni, S.,Lewandowski, T.,Van Aller, G.S.,Zonis, R.,Ward, P.,Campobasso, N. Acylprolinamides: a new class of peptide deformylase inhibitors with in vivo antibacterial activity. Bioorg.Med.Chem.Lett., 22:4028-4032, 2012 Cited by PubMed: 22579486DOI: 10.1016/j.bmcl.2012.04.086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.783 Å) |
Structure validation
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