4ENX

Crystal Structure of Pim-1 Kinase in complex with inhibitor (2E,5Z)-2-(2-chlorophenylimino)-5-(4-hydroxy-3-nitrobenzylidene)thiazolidin-4-one

4ENX の概要

• エントリーDOI: 10.2210/pdb4enx/pdb
• 関連するPDBエントリー: 3UIX 3UMW 3UMX 4ENY
• 分子名称: Serine/threonine-protein kinase pim-1, PHOSPHATE ION, (2Z,5Z)-2-[(2-chlorophenyl)imino]-5-(4-hydroxy-3-nitrobenzylidene)-1,3-thiazolidin-4-one, ... (4 entities in total)
• 機能のキーワード: pim-1 kinase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34658.48

構造登録者

Parker, L.J.,Handa, N.,Yokoyama, S. (登録日: 2012-04-13, 公開日: 2012-08-08, 最終更新日: 2023-11-08)

• 主引用文献: Parker, L.J.,Watanabe, H.,Tsuganezawa, K.,Tomabechi, Y.,Handa, N.,Shirouzu, M.,Yuki, H.,Honma, T.,Ogawa, N.,Nagano, T.,Yokoyama, S.,Tanaka, A.; Flexibility of the P-loop of Pim-1 kinase: observation of a novel conformation induced by interaction with an inhibitor; Acta Crystallogr.,Sect.F, 68:860-866, 2012; PubMed: 22869110; DOI: 10.1107/S1744309112027108

実験手法

X-RAY DIFFRACTION (2.8 Å)