4EN2
HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain)
Summary for 4EN2
Entry DOI | 10.2210/pdb4en2/pdb |
Related | 4EMZ |
Descriptor | AP-1 complex subunit mu-1, Protein Nef, MHC-I, ... (4 entities in total) |
Functional Keywords | human immunodeficiency virus 1, hiv, nef, mhc-i, antigen presentation, host defense, adaptor protein complex 1, mu1 adaptin subunit, sorting motif recognition, clasp, membrane trafficking, viral hijacking, viral protein-immune system complex, viral protein/immune system |
Biological source | Mus musculus (mouse) More |
Cellular location | Golgi apparatus: P35585 Host cell membrane ; Lipid-anchor ; Cytoplasmic side : Q90VU7 |
Total number of polymer chains | 6 |
Total formula weight | 113520.66 |
Authors | |
Primary citation | Jia, X.,Singh, R.,Homann, S.,Yang, H.,Guatelli, J.,Xiong, Y. Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat.Struct.Mol.Biol., 19:701-706, 2012 Cited by PubMed: 22705789DOI: 10.1038/nsmb.2328 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
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