4EN2

HIV-1 Nef in complex with MHC-I cytoplasmic domain and Mu1 adaptin subunit of AP1 adaptor (second domain)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006886	biological_process	intracellular protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0030131	cellular_component	clathrin adaptor complex
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005576	cellular_component	extracellular region
B	0010561	biological_process	negative regulation of glycoprotein biosynthetic process
B	0016020	cellular_component	membrane
B	0017124	molecular_function	SH3 domain binding
B	0019058	biological_process	viral life cycle
B	0019901	molecular_function	protein kinase binding
B	0020002	cellular_component	host cell plasma membrane
B	0031996	molecular_function	thioesterase binding
B	0033668	biological_process	symbiont-mediated suppression of host apoptosis
B	0039504	biological_process	symbiont-mediated suppression of host adaptive immune response
B	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
B	0042288	molecular_function	MHC class I protein binding
B	0042609	molecular_function	CD4 receptor binding
B	0044178	cellular_component	host cell Golgi membrane
B	0044423	cellular_component	virion component
B	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
B	0050848	biological_process	regulation of calcium-mediated signaling
B	0051117	molecular_function	ATPase binding
B	0051246	biological_process	regulation of protein metabolic process
B	0051701	biological_process	biological process involved in interaction with host
B	0052031	biological_process	symbiont-mediated perturbation of host defense response
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0070206	biological_process	protein trimerization
B	0140321	biological_process	symbiont-mediated suppression of host autophagy
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005576	cellular_component	extracellular region
C	0010561	biological_process	negative regulation of glycoprotein biosynthetic process
C	0016020	cellular_component	membrane
C	0017124	molecular_function	SH3 domain binding
C	0019058	biological_process	viral life cycle
C	0019901	molecular_function	protein kinase binding
C	0020002	cellular_component	host cell plasma membrane
C	0031996	molecular_function	thioesterase binding
C	0033668	biological_process	symbiont-mediated suppression of host apoptosis
C	0039504	biological_process	symbiont-mediated suppression of host adaptive immune response
C	0039505	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
C	0042288	molecular_function	MHC class I protein binding
C	0042609	molecular_function	CD4 receptor binding
C	0044178	cellular_component	host cell Golgi membrane
C	0044423	cellular_component	virion component
C	0046776	biological_process	symbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0051117	molecular_function	ATPase binding
C	0051246	biological_process	regulation of protein metabolic process
C	0051701	biological_process	biological process involved in interaction with host
C	0052031	biological_process	symbiont-mediated perturbation of host defense response
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0070206	biological_process	protein trimerization
C	0140321	biological_process	symbiont-mediated suppression of host autophagy
D	0006955	biological_process	immune response
D	0019882	biological_process	antigen processing and presentation
E	0006955	biological_process	immune response
E	0019882	biological_process	antigen processing and presentation
M	0006886	biological_process	intracellular protein transport
M	0016192	biological_process	vesicle-mediated transport
M	0030131	cellular_component	clathrin adaptor complex

Functional Information from PROSITE/UniProt

site_id	PS00991
Number of Residues	15
Details	CLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmsY

Chain	Residue	Details
M	ILE253-TYR267

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q32Q06","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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