4EKG
Crystal Structure of DOT1L in Complex with EPZ003696
Summary for 4EKG
Entry DOI | 10.2210/pdb4ekg/pdb |
Related | 3QOW 4EK9 4EKI |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-79 specific, 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(methyl)amino]-5'-deoxyadenosine (3 entities in total) |
Functional Keywords | methyltransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (Probable): Q8TEK3 |
Total number of polymer chains | 1 |
Total formula weight | 49078.84 |
Authors | |
Primary citation | Basavapathruni, A.,Jin, L.,Daigle, S.R.,Majer, C.R.,Therkelsen, C.A.,Wigle, T.J.,Kuntz, K.W.,Chesworth, R.,Pollock, R.M.,Scott, M.P.,Moyer, M.P.,Richon, V.M.,Copeland, R.A.,Olhava, E.J. Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des., 80:971-980, 2012 Cited by PubMed: 22978415DOI: 10.1111/cbdd.12050 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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