4EKG
Crystal Structure of DOT1L in Complex with EPZ003696
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase, H3 lysine-79 specific | polymer | 425 | 48566.2 | 1 | UniProt (Q8TEK3) Pfam (PF08123) | Homo sapiens (human) | DOT1-like protein, Histone H3-K79 methyltransferase, H3-K79-HMTase, Lysine N-methyltransferase 4 |
| 2 | B (A) | 5'-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(methyl)amino]-5'-deoxyadenosine | non-polymer | 512.6 | 1 | Chemie (0QJ) | |||
| 3 | C (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 1 - 416 (UniProt: Q8TEK3)
| PDB | External Database | Details |
|---|---|---|
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48566.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 512.6 | |
| All* | Total formula weight | 49078.8 |
