4EJ1
Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex
Summary for 4EJ1
Entry DOI | 10.2210/pdb4ej1/pdb |
Related | 4EIG 4EIZ |
Descriptor | Dihydrofolate reductase, Nb113 camelid antibody fragment, FOLIC ACID, ... (5 entities in total) |
Functional Keywords | folate, oxidoreductase-immune system complex, oxidoreductase/immune system |
Biological source | Escherichia coli More |
Total number of polymer chains | 4 |
Total formula weight | 67121.81 |
Authors | Oyen, D.,Srinivasan, V. (deposition date: 2012-04-06, release date: 2013-04-24, Last modification date: 2013-10-30) |
Primary citation | Oyen, D.,Wechselberger, R.,Srinivasan, V.,Steyaert, J.,Barlow, J.N. Mechanistic analysis of allosteric and non-allosteric effects arising from nanobody binding to two epitopes of the dihyrofolate reductase of Escherichia coli. Biochim.Biophys.Acta, 1834:2147-2157, 2013 Cited by PubMed: 23911607DOI: 10.1016/j.bbapap.2013.07.010 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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