4EIN

Crystal structure of mouse thymidylate synthase in binary complex with a substrate analogue and strong inhibitor, N(4)-hydroxy-2'-deoxycytidine-5'-monophosphate

4EIN の概要

• エントリーDOI: 10.2210/pdb4ein/pdb
• 分子名称: Thymidylate synthase, 2'-deoxy-N-hydroxycytidine 5'-(dihydrogen phosphate), GLYCEROL, ... (4 entities in total)
• 機能のキーワード: methyltransferase, binding site, catalysis, dimerization, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mus musculus (mouse)
• 細胞内の位置: Nucleus (By similarity): P07607
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70740.52

構造登録者

Dowiercial, A.,Jarmula, A.,Rypniewski, W.R.,Wilk, P.,Kierdaszuk, B.,Rode, W. (登録日: 2012-04-05, 公開日: 2013-04-10, 最終更新日: 2023-09-13)

• 主引用文献: Dowiercial, A.,Jarmula, A.,Rypniewski, W.R.,Wilk, P.,Kierdaszuk, B.,Rode, W.; Crystal structures of complexes of mouse thymidylate synthase crystallized with N4-OH-dCMP alone or in the presence of N5,10-methylenetetrahydrofolate; PTERIDINES, 2013

実験手法

X-RAY DIFFRACTION (1.75 Å)