4EGC

Crystal Structure of MBP-fused Human Six1 Bound to Human Eya2 Eya Domain

Summary for 4EGC

Entry DOI	10.2210/pdb4egc/pdb
Related PRD ID	PRD_900001
Descriptor	Maltose-binding periplasmic protein, Homeobox protein SIX1 chimera, Eyes absent homolog 2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (5 entities in total)
Functional Keywords	homeodomain (hd), six domain (sd), eya domain (ed), haloacid dehalogenase (had), transcription factor, co-activator, protein phosphatase, dna binding, fusion protein, nucleus, transcription-hydrolase complex, transcription/hydrolase
Biological source	Escherichia coli (human) More
Total number of polymer chains	2
Total formula weight	95895.95
Authors	Zhao, R.,Patrick, A.N. (deposition date: 2012-03-30, release date: 2013-02-27, Last modification date: 2024-02-28)
Primary citation	Patrick, A.N.,Cabrera, J.H.,Smith, A.L.,Chen, X.S.,Ford, H.L.,Zhao, R. Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome. Nat.Struct.Mol.Biol., 20:447-453, 2013 Cited by PubMed: 23435380 DOI: 10.1038/nsmb.2505 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.994 Å)

Structure validation