4EGA
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1320
Summary for 4EGA
Entry DOI | 10.2210/pdb4ega/pdb |
Related | 4EG1 4EG3 4EG4 4EG5 4EG6 4EG7 4EG8 |
Descriptor | Methionyl-tRNA synthetase, putative, GLYCEROL, DIMETHYL SULFOXIDE, ... (7 entities in total) |
Functional Keywords | aminoacyl-trna synthetase, aars, metrs, parasite, ligase, protein-inhibitor complex, rossmann-fold, translation, nucleotide binding, rossmann fold, trna binding, atp binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Trypanosoma brucei brucei |
Total number of polymer chains | 2 |
Total formula weight | 125930.38 |
Authors | Koh, C.Y.,Kim, J.E.,Shibata, S.,Fan, E.,Verlinde, C.L.M.J.,Hol, W.G.J. (deposition date: 2012-03-30, release date: 2012-09-12, Last modification date: 2023-09-13) |
Primary citation | Koh, C.Y.,Kim, J.E.,Shibata, S.,Ranade, R.M.,Yu, M.,Liu, J.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G. Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection. Structure, 20:1681-1691, 2012 Cited by PubMed: 22902861DOI: 10.1016/j.str.2012.07.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.698 Å) |
Structure validation
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