4EGA
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1320
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Methionyl-tRNA synthetase, putative | polymer | 542 | 61538.7 | 2 | UniProt (Q38C91) Pfam (PF09334) Pfam (PF19303) | Trypanosoma brucei brucei | |
| 2 | C, D, E, F, G... (A, B) | GLYCEROL | non-polymer | 92.1 | 17 | Chemie (GOL) | |||
| 3 | AA, L, M, N, O... (B, A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 7 | Chemie (DMS) | |||
| 4 | P (A) | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) | |||
| 5 | BA (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | CA (B) | 2-({3-[(3,5-dibromo-2-methoxybenzyl)amino]propyl}amino)quinolin-4(1H)-one | non-polymer | 495.2 | 1 | Chemie (0P8) | |||
| 7 | DA, EA (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, B: 237 - 773 (UniProt: Q38C91)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Met 0 | - | expression tag |
| Thr 309 | Ala 309 | conflict |
| Ala 452 | Lys 452 | engineered mutation |
| Arg 453 | Lys 453 | engineered mutation |
| Ala 454 | Glu 454 | engineered mutation |
| Val 499 | Ala 499 | conflict |
| Asn 503 | Ser 503 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 123077.4 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 2853.0 | |
| All* | Total formula weight | 125930.4 |
