4EG4

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1289

4EG4 の概要

• エントリーDOI: 10.2210/pdb4eg4/pdb
• 関連するPDBエントリー: 4EG1 4EG3 4EG4 4EG5 4EG6 4EG7 4EG8 4EGA
• 分子名称: Methionyl-tRNA synthetase, putative, GLYCEROL, DIMETHYL SULFOXIDE, ... (7 entities in total)
• 機能のキーワード: aminoacyl-trna synthetase, aars, metrs, parasite, ligase, protein-inhibitor complex, rossmann-fold, translation, nucleotide binding, rossmann fold, trna binding atp binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Trypanosoma brucei brucei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 126142.55

構造登録者

Koh, C.Y.,Kim, J.E.,Shibata, S.,Fan, E.,Verlinde, C.L.M.J.,Hol, W.G.J. (登録日: 2012-03-30, 公開日: 2012-09-12, 最終更新日: 2023-09-13)

• 主引用文献: Koh, C.Y.,Kim, J.E.,Shibata, S.,Ranade, R.M.,Yu, M.,Liu, J.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G.; Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection.; Structure, 20:1681-1691, 2012; PubMed: 22902861; DOI: 10.1016/j.str.2012.07.011

実験手法

X-RAY DIFFRACTION (3.151 Å)