4EG4
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor Chem 1289
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Methionyl-tRNA synthetase, putative | polymer | 542 | 61538.7 | 2 | UniProt (Q38C91) Pfam (PF09334) Pfam (PF19303) In PDB | Trypanosoma brucei brucei | |
2 | B, A | GLYCEROL | non-polymer | 92.1 | 20 | Chemie (GOL) | |||
3 | B, A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 6 | Chemie (DMS) | |||
4 | A | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) | |||
5 | B | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
6 | B | 2-({3-[(3,5-dibromo-2-ethoxybenzyl)amino]propyl}amino)quinolin-4(1H)-one | non-polymer | 509.2 | 1 | Chemie (0OT) | |||
7 | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A, B: 237 - 773 (UniProt: Q38C91)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Met 0 | - | expression tag |
Thr 309 | Ala 309 | conflict |
Ala 452 | Lys 452 | engineered mutation |
Arg 453 | Lys 453 | engineered mutation |
Ala 454 | Glu 454 | engineered mutation |
Val 499 | Ala 499 | conflict |
Asn 503 | Ser 503 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 123077.4 | |
Non-Polymers* | Number of molecules | 29 |
Total formula weight | 3065.2 | |
All* | Total formula weight | 126142.6 |