4EFU

Hsp90 Alpha N-terminal Domain in Complex with an Inhibitor 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid benzyl-methyl-amide

4EFU の概要

• エントリーDOI: 10.2210/pdb4efu/pdb
• 関連するPDBエントリー: 3B28 4EEH 4EFT
• 分子名称: Heat shock protein HSP 90-alpha, N-benzyl-6-hydroxy-N-methyl-3-(3-methylbenzyl)-1H-indazole-5-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: atp binding, chaperone-chaperone inhibitor complex, chaperone/chaperone inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P07900
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26195.34

構造登録者

Musil, D.,Lehmann, M.,Graedler, U.,Buchstaller, H.-P. (登録日: 2012-03-30, 公開日: 2012-06-27, 最終更新日: 2024-03-20)

• 主引用文献: Buchstaller, H.-P.,Eggenweiler, H.-M.,Sirrenberg, C.,Graedler, U.,Musil, D.,Hoppe, E.,Zimmermann, A.,Schwartz, H.,Maerz, J.,Bomke, J.,Wegener, A.,Wolf, M.; Fragment-based discovery of hydroxy-indazole-carboxamides as novel small molecule inhibitors of Hsp90; Bioorg.Med.Chem.Lett., 22:4396-4403, 2012; PubMed: 22632933; DOI: 10.1016/j.bmcl.2012.04.121

実験手法

X-RAY DIFFRACTION (2 Å)