4EFS

Human MMP12 in complex with L-glutamate motif inhibitor

Summary for 4EFS

Entry DOI	10.2210/pdb4efs/pdb
Related	3LIK 3LIL 3LIR 3LJG 3TS4
Descriptor	Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (10 entities in total)
Functional Keywords	pseudo peptides, potent inhibitors, metzincin, zinc protease, l-glutamate motif inhibitors, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	1
Total formula weight	18864.88
Authors	Stura, E.A.,Dive, V.,Devel, L.,Czarny, B.,Beau, F.,Vera, L. (deposition date: 2012-03-30, release date: 2012-06-20, Last modification date: 2023-09-13)
Primary citation	Devel, L.,Beau, F.,Amoura, M.,Vera, L.,Cassar-Lajeunesse, E.,Garcia, S.,Czarny, B.,Stura, E.A.,Dive, V. Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins. J.Biol.Chem., 287:26647-26656, 2012 Cited by PubMed: 22689580 DOI: 10.1074/jbc.M112.380782 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation