4EDW

Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911 (tanezumab)

4EDW の概要

• エントリーDOI: 10.2210/pdb4edw/pdb
• 関連するPDBエントリー: 4EDX
• 分子名称: Beta-nerve growth factor, tanezumab Fab light chain, tanezumab Fab heavy chain, ... (5 entities in total)
• 機能のキーワード: cystine knot, immunoglobulin, growth/survival factor, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01138
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 62188.41

構造登録者

Eigenbrot, C.,Ultsch, M. (登録日: 2012-03-27, 公開日: 2014-04-02, 最終更新日: 2017-10-25)

• 主引用文献: La Porte, S.L.,Eigenbrot, C.,Ultsch, M.,Ho, W.H.,Foletti, D.,Forgie, A.,Lindquist, K.C.,Shelton, D.L.,Pons, J.; Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes.; MAbs, 6:1059-1068, ; PubMed: 24830649

実験手法

X-RAY DIFFRACTION (2.48 Å)