4ED4

Crystal structure of IspE (4-diphosphocytidyl-2-C-methyl-D-erythritol kinase) from Mycobacterium abcessus, bound to ATP

Summary for 4ED4

• Entry DOI: 10.2210/pdb4ed4/pdb
• Related: 4DXL
• Descriptor: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ADENOSINE-5'-TRIPHOSPHATE (3 entities in total)
• Functional Keywords: ssgcid, nih, niaid, sbri, emerald biostructures, structural genomics, seattle structural genomics center for infectious disease, transferase
• Biological source: Mycobacterium abscessus
• Total number of polymer chains: 1
• Total formula weight: 33249.76

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2012-03-26, release date: 2012-04-04, Last modification date: 2023-09-13)

• Primary citation: Baugh, L.,Phan, I.,Begley, D.W.,Clifton, M.C.,Armour, B.,Dranow, D.M.,Taylor, B.M.,Muruthi, M.M.,Abendroth, J.,Fairman, J.W.,Fox, D.,Dieterich, S.H.,Staker, B.L.,Gardberg, A.S.,Choi, R.,Hewitt, S.N.,Napuli, A.J.,Myers, J.,Barrett, L.K.,Zhang, Y.,Ferrell, M.,Mundt, E.,Thompkins, K.,Tran, N.,Lyons-Abbott, S.,Abramov, A.,Sekar, A.,Serbzhinskiy, D.,Lorimer, D.,Buchko, G.W.,Stacy, R.,Stewart, L.J.,Edwards, T.E.,Van Voorhis, W.C.,Myler, P.J.; Increasing the structural coverage of tuberculosis drug targets.; Tuberculosis (Edinb), 95:142-148, 2015; PubMed: 25613812; DOI: 10.1016/j.tube.2014.12.003

Experimental method

X-RAY DIFFRACTION (1.75 Å)