4EBW

Structure of Focal Adhesion Kinase catalytic domain in complex with novel allosteric inhibitor

4EBW の概要

• エントリーDOI: 10.2210/pdb4ebw/pdb
• 関連するPDBエントリー: 4EBV
• 分子名称: Focal adhesion kinase 1, 1-ethyl-8-(4-ethylphenyl)-5-methyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazine 4,4-dioxide (3 entities in total)
• 機能のキーワード: kinase domain, allosteric inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell junction, focal adhesion: Q05397
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35461.78

構造登録者

Iwatani, M.,Iwata, H.,Okabe, A.,Skene, R.J.,Tomita, N.,Hayashi, Y.,Aramaki, Y.,Hosfield, D.J.,Hori, A.,Baba, A.,Miki, H. (登録日: 2012-03-25, 公開日: 2012-07-25, 最終更新日: 2013-03-27)

• 主引用文献: Iwatani, M.,Iwata, H.,Okabe, A.,Skene, R.J.,Tomita, N.,Hayashi, Y.,Aramaki, Y.,Hosfield, D.J.,Hori, A.,Baba, A.,Miki, H.; Discovery and characterization of novel allosteric FAK inhibitors.; Eur.J.Med.Chem., 61:49-60, 2013; PubMed: 22819505; DOI: 10.1016/j.ejmech.2012.06.035

実験手法

X-RAY DIFFRACTION (2.65 Å)