4EA3

Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic

4EA3 の概要

• エントリーDOI: 10.2210/pdb4ea3/pdb
• 分子名称: Fusion protein of Nociceptin receptor and cytochrome b562, 1-benzyl-N-[3-(1'H,3H-spiro[2-benzofuran-1,4'-piperidin]-1'-yl)propyl]-D-prolinamide, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (6 entities in total)
• 機能のキーワード: psi-biology gpcr network, structural genomics, gpcr membrane protein 7tm nop orl1 cytochrome b562, receptor, nociceptin orphanin fq compound 24 opioid, fusion, membrane transmembrane, signaling protein
• 由来する生物種: Escherichia coli; 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P41146
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98018.35

構造登録者

Thompson, A.A.,Liu, W.,Chun, E.,Katritch, V.,Wu, H.,Vardy, E.,Huang, X.P.,Trapella, C.,Guerrini, R.,Calo, G.,Roth, B.L.,Cherezov, V.,Stevens, R.C.,GPCR Network (GPCR) (登録日: 2012-03-22, 公開日: 2012-04-25, 最終更新日: 2023-09-13)

• 主引用文献: Thompson, A.A.,Liu, W.,Chun, E.,Katritch, V.,Wu, H.,Vardy, E.,Huang, X.P.,Trapella, C.,Guerrini, R.,Calo, G.,Roth, B.L.,Cherezov, V.,Stevens, R.C.; Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.; Nature, 485:395-399, 2012; PubMed: 22596163; DOI: 10.1038/nature11085

実験手法

X-RAY DIFFRACTION (3.013 Å)