4E92
Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BM4
Summary for 4E92
Entry DOI | 10.2210/pdb4e92/pdb |
Related | 4E91 |
Descriptor | Gag protein, 4-{2-[5-(3-chlorophenyl)-1H-pyrazol-4-yl]-1-[3-(1H-imidazol-1-yl)propyl]-1H-benzimidazol-5-yl}benzoic acid, 3-{5-[3-ethyl-5-(5-methylfuran-2-yl)-1H-pyrazol-1-yl]-1-[(6-oxo-1,6-dihydropyridin-3-yl)methyl]-1H-benzimidazol-2-yl}-4-hydroxybenzoic acid, ... (4 entities in total) |
Functional Keywords | structural protein capsid, structural protein-inhibitor complex, structural protein/inhibitor |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Capsid protein p24: Virion (By similarity). Matrix protein p17: Virion (By similarity). Nucleocapsid protein p7: Virion (By similarity): Q79791 |
Total number of polymer chains | 2 |
Total formula weight | 34526.22 |
Authors | Lemke, C.T. (deposition date: 2012-03-20, release date: 2012-04-25, Last modification date: 2024-02-28) |
Primary citation | Lemke, C.T.,Titolo, S.,von Schwedler, U.,Goudreau, N.,Mercier, J.F.,Wardrop, E.,Faucher, A.M.,Coulombe, R.,Banik, S.S.,Fader, L.,Gagnon, A.,Kawai, S.H.,Rancourt, J.,Tremblay, M.,Yoakim, C.,Simoneau, B.,Archambault, J.,Sundquist, W.I.,Mason, S.W. Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein. J.Virol., 86:6643-6655, 2012 Cited by PubMed: 22496222DOI: 10.1128/JVI.00493-12 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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