4E91

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With Inhibitor BD3

Summary for 4E91

• Entry DOI: 10.2210/pdb4e91/pdb
• Related: 4E92
• Descriptor: Gag protein, 4-{2-[5-(3-chlorophenyl)-1H-pyrazol-4-yl]-1-[3-(1H-imidazol-1-yl)propyl]-1H-benzimidazol-5-yl}benzoic acid, (3S)-1-ethyl-3-[3-hydroxy-5-(pyridin-3-yl)phenyl]-5-phenyl-7-(trifluoromethyl)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione, ... (5 entities in total)
• Functional Keywords: structural protein capsid, structural protein, structural protein-inhibitor complex, structural protein/inhibitor
• Biological source: Human immunodeficiency virus 1
• Cellular location: Capsid protein p24: Virion (By similarity). Matrix protein p17: Virion (By similarity). Nucleocapsid protein p7: Virion (By similarity): Q79791
• Total number of polymer chains: 2
• Total formula weight: 34480.23

Authors

Lemke, C.T. (deposition date: 2012-03-20, release date: 2012-04-25, Last modification date: 2024-02-28)

• Primary citation: Lemke, C.T.,Titolo, S.,von Schwedler, U.,Goudreau, N.,Mercier, J.F.,Wardrop, E.,Faucher, A.M.,Coulombe, R.,Banik, S.S.,Fader, L.,Gagnon, A.,Kawai, S.H.,Rancourt, J.,Tremblay, M.,Yoakim, C.,Simoneau, B.,Archambault, J.,Sundquist, W.I.,Mason, S.W.; Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein.; J.Virol., 86:6643-6655, 2012; PubMed: 22496222; DOI: 10.1128/JVI.00493-12

Experimental method

X-RAY DIFFRACTION (1.7 Å)