4E8Y

Crystal Structure of Burkholderia cenocepacia HldA in Complex with an ATP-competitive Inhibitor

Summary for 4E8Y

Entry DOI	10.2210/pdb4e8y/pdb
Related	4E84 4E8W 4E8Z
Descriptor	D-beta-D-heptose 7-phosphate kinase, {[2-({[5-(2,6-dimethoxyphenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetic acid, 7-O-phosphono-D-glycero-beta-D-manno-heptopyranose, ... (7 entities in total)
Functional Keywords	lps-heptose biosynthesis, beta-clasp dimerization region, pfkb carbohydrate kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Burkholderia cenocepacia
Total number of polymer chains	2
Total formula weight	78180.67
Authors	Lee, T.-W.,Verhey, T.B.,Junop, M.S. (deposition date: 2012-03-20, release date: 2012-12-26, Last modification date: 2023-09-13)
Primary citation	Lee, T.W.,Verhey, T.B.,Antiperovitch, P.A.,Atamanyuk, D.,Desroy, N.,Oliveira, C.,Denis, A.,Gerusz, V.,Drocourt, E.,Loutet, S.A.,Hamad, M.A.,Stanetty, C.,Andres, S.N.,Sugiman-Marangos, S.,Kosma, P.,Valvano, M.A.,Moreau, F.,Junop, M.S. Structural-functional studies of Burkholderia cenocepacia D-glycero-beta-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties. J.Med.Chem., 56:1405-1417, 2013 Cited by PubMed: 23256532 DOI: 10.1021/jm301483h PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation