4E8W

Crystal Structure of Burkholderia cenocepacia HldA in Complex with an ATP-competitive Inhibitor

4E8W の概要

• エントリーDOI: 10.2210/pdb4e8w/pdb
• 関連するPDBエントリー: 4E84 4E8Y 4E8Z
• 分子名称: D-beta-D-heptose 7-phosphate kinase, {[2-({[5-(2,6-dimethoxyphenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetic acid, POTASSIUM ION, ... (4 entities in total)
• 機能のキーワード: lps-heptose biosynthesis, beta-clasp dimerization region, pfkb carbohydrate kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Burkholderia cenocepacia
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77724.63

構造登録者

Lee, T.-W.,Verhey, T.B.,Junop, M.S. (登録日: 2012-03-20, 公開日: 2012-12-26, 最終更新日: 2023-09-13)

• 主引用文献: Lee, T.W.,Verhey, T.B.,Antiperovitch, P.A.,Atamanyuk, D.,Desroy, N.,Oliveira, C.,Denis, A.,Gerusz, V.,Drocourt, E.,Loutet, S.A.,Hamad, M.A.,Stanetty, C.,Andres, S.N.,Sugiman-Marangos, S.,Kosma, P.,Valvano, M.A.,Moreau, F.,Junop, M.S.; Structural-functional studies of Burkholderia cenocepacia D-glycero-beta-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.; J.Med.Chem., 56:1405-1417, 2013; PubMed: 23256532; DOI: 10.1021/jm301483h

実験手法

X-RAY DIFFRACTION (2.8654 Å)