4E8Z
Crystal Structure of Burkholderia cenocepacia HldA in Complex with an ATP-competitive Inhibitor
Summary for 4E8Z
Entry DOI | 10.2210/pdb4e8z/pdb |
Related | 4E84 4E8W 4E8Y |
Descriptor | D-beta-D-heptose 7-phosphate kinase, {[2-({[5-(2,6-dichlorophenyl)-1,2,4-triazin-3-yl]amino}methyl)-1,3-benzothiazol-5-yl]oxy}acetic acid, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | lps-heptose biosynthesis, beta-clasp dimerization region, pfkb carbohydrate kinase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Burkholderia cenocepacia |
Total number of polymer chains | 2 |
Total formula weight | 77742.31 |
Authors | Lee, T.-W.,Verhey, T.B.,Junop, M.S. (deposition date: 2012-03-20, release date: 2012-12-26, Last modification date: 2023-09-13) |
Primary citation | Lee, T.W.,Verhey, T.B.,Antiperovitch, P.A.,Atamanyuk, D.,Desroy, N.,Oliveira, C.,Denis, A.,Gerusz, V.,Drocourt, E.,Loutet, S.A.,Hamad, M.A.,Stanetty, C.,Andres, S.N.,Sugiman-Marangos, S.,Kosma, P.,Valvano, M.A.,Moreau, F.,Junop, M.S. Structural-functional studies of Burkholderia cenocepacia D-glycero-beta-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties. J.Med.Chem., 56:1405-1417, 2013 Cited by PubMed: 23256532DOI: 10.1021/jm301483h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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