4E78
Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
4E78 の概要
エントリーDOI | 10.2210/pdb4e78/pdb |
関連するPDBエントリー | 4E76 4E7A |
分子名称 | 5'-R(*U*AP*CP*CP*GP*(GDO))-3', PROTEIN (RNA-directed RNA polymerase) (3 entities in total) |
機能のキーワード | rdrp, loopless delta8, ternary complex, product complex, flaviviridae, hepatitis c virus, viral protein, transferase-rna complex, transferase/rna |
由来する生物種 | Hepatitis C virus (HCV) 詳細 |
細胞内の位置 | Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : Q99IB8 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 67486.58 |
構造登録者 | |
主引用文献 | Mosley, R.T.,Edwards, T.E.,Murakami, E.,Lam, A.M.,Grice, R.L.,Du, J.,Sofia, M.J.,Furman, P.A.,Otto, M.J. Structure of hepatitis C virus polymerase in complex with primer-template RNA. J.Virol., 86:6503-6511, 2012 Cited by PubMed: 22496223DOI: 10.1128/JVI.00386-12 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.9 Å) |
構造検証レポート
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