4E5J

Crystal structure of avian influenza virus PAn bound to compound 5

Summary for 4E5J

Entry DOI	10.2210/pdb4e5j/pdb
Related	4E5E 4E5F 4E5G 4E5H 4E5I 4E5L
Descriptor	Polymerase protein PA, SULFATE ION, 2-[3-(acetylamino)phenyl]-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid, ... (5 entities in total)
Functional Keywords	endonuclease domain, h5n1 subtype, viral protein, transcription
Biological source	Influenza A virus More
Cellular location	Host cytoplasm . Host nucleus : Q5EP34
Total number of polymer chains	4
Total formula weight	91185.80
Authors	DuBois, R.M.,Slavish, P.J.,Webb, T.R.,White, S.W. (deposition date: 2012-03-14, release date: 2012-08-08, Last modification date: 2023-09-13)
Primary citation	Dubois, R.M.,Slavish, P.J.,Baughman, B.M.,Yun, M.K.,Bao, J.,Webby, R.J.,Webb, T.R.,White, S.W. Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease. Plos Pathog., 8:e1002830-e1002830, 2012 Cited by PubMed: 22876176 DOI: 10.1371/journal.ppat.1002830 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation