4E47

SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine

Summary for 4E47

• Entry DOI: 10.2210/pdb4e47/pdb
• Descriptor: Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, ... (6 entities in total)
• Functional Keywords: ternary complex, set domain, methyltransferase, inhibitor, s-adenosylmethionine, chromatin regulator, chromosomal protein, nucleus, transcription, transcription regulation, transferase, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q8WTS6
• Total number of polymer chains: 4
• Total formula weight: 122257.92

Authors

Walker, J.R.,Ouyang, H.,Dong, A.,Fish, P.,Cook, A.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2012-03-12, release date: 2012-03-28, Last modification date: 2023-09-13)

• Primary citation: Walker, J.R.,Ouyang, H.,Dong, A.,Fish, P.,Cook, A.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC); Setd7 in Complex with Inhibitor and SAM; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)