4E47

SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine

4E47 の概要

• エントリーDOI: 10.2210/pdb4e47/pdb
• 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, ... (6 entities in total)
• 機能のキーワード: ternary complex, set domain, methyltransferase, inhibitor, s-adenosylmethionine, chromatin regulator, chromosomal protein, nucleus, transcription, transcription regulation, transferase, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q8WTS6
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 122257.92

構造登録者

Walker, J.R.,Ouyang, H.,Dong, A.,Fish, P.,Cook, A.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) (登録日: 2012-03-12, 公開日: 2012-03-28, 最終更新日: 2023-09-13)

• 主引用文献: Walker, J.R.,Ouyang, H.,Dong, A.,Fish, P.,Cook, A.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC); Setd7 in Complex with Inhibitor and SAM; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)