4E2I

The Complex Structure of the SV40 Helicase Large T Antigen and p68 Subunit of DNA Polymerase Alpha-Primase

Summary for 4E2I

Entry DOI	10.2210/pdb4e2i/pdb
Descriptor	Large T antigen, DNA polymerase alpha subunit B, ZINC ION (3 entities in total)
Functional Keywords	replication initiation, hydrolase-dna binding complex, hydrolase-dna binding protein complex, hydrolase/dna binding protein
Biological source	Simian virus 40 (SV40) More
Cellular location	Nucleus: Q14181
Total number of polymer chains	23
Total formula weight	598246.55
Authors	Zhou, B.,Arnett, D.R.,Yu, X.,Brewster, A.,Sowd, G.A.,Xie, C.L.,Vila, S.,Gai, D.,Fanning, E.,Chen, X.S. (deposition date: 2012-03-08, release date: 2012-06-13, Last modification date: 2024-02-28)
Primary citation	Zhou, B.,Arnett, D.R.,Yu, X.,Brewster, A.,Sowd, G.A.,Xie, C.L.,Vila, S.,Gai, D.,Fanning, E.,Chen, X.S. Structural basis for the interaction of a hexameric replicative helicase with the regulatory subunit of human DNA polymerase alpha-primase. J.Biol.Chem., 287:26854-26866, 2012 Cited by PubMed: 22700977 DOI: 10.1074/jbc.M112.363655 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (5 Å)

Structure validation