4E26
BRAF in complex with an organic inhibitor 7898734
Summary for 4E26
| Entry DOI | 10.2210/pdb4e26/pdb |
| Descriptor | Serine/threonine-protein kinase B-raf, 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol (3 entities in total) |
| Functional Keywords | kinase, inhibitor, oncoprotein, melanoma, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus (By similarity): P15056 |
| Total number of polymer chains | 2 |
| Total formula weight | 71138.84 |
| Authors | Qin, J.,Xie, P.,Ventocilla, C.,Zhou, G.,Vultur, A.,Chen, Q.,Herlyn, M.,Winkler, J.,Marmorstein, R. (deposition date: 2012-03-07, release date: 2012-05-09, Last modification date: 2024-02-28) |
| Primary citation | Qin, J.,Xie, P.,Ventocilla, C.,Zhou, G.,Vultur, A.,Chen, Q.,Liu, Q.,Herlyn, M.,Winkler, J.,Marmorstein, R. Identification of a Novel Family of BRAF(V600E) Inhibitors. J.Med.Chem., 55:5220-5230, 2012 Cited by PubMed: 22537109DOI: 10.1021/jm3004416 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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