Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4E26

BRAF in complex with an organic inhibitor 7898734

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BSerine/threonine-protein kinase B-rafpolymer30735217.62UniProt (P15056)
Pfam (PF07714)
In PDB
Homo sapiens (human)Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1
2A, B5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-olnon-polymer351.82Chemie (734)
3waterwater18.076Chemie (HOH)
Sequence modifications
A, B: 432 - 726 (UniProt: P15056)
PDBExternal DatabaseDetails
Met 420-expression tag
Asp 421-expression tag
Arg 422-expression tag
Gly 423-expression tag
Ser 424-expression tag
His 425-expression tag
His 426-expression tag
His 427-expression tag
His 428-expression tag
His 429-expression tag
His 430-expression tag
Gly 431-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight70435.3
Non-Polymers*Number of molecules2
Total formula weight703.6
All*Total formula weight71138.8
*Water molecules are not included.

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon