4E1Z
Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
Summary for 4E1Z
Entry DOI | 10.2210/pdb4e1z/pdb |
Related | 4E20 |
Descriptor | Non-receptor tyrosine-protein kinase TYK2, N-[5-(4-{[(3-chlorophenyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]furan-2-carboxamide (3 entities in total) |
Functional Keywords | kinase catalytic domain, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mus musculus (mouse) |
Total number of polymer chains | 1 |
Total formula weight | 34189.47 |
Authors | Argiriadi, M.A.,Talanian, R.V.,Borhani, D.W. (deposition date: 2012-03-07, release date: 2012-10-03, Last modification date: 2024-02-28) |
Primary citation | Argiriadi, M.A.,Goedken, E.R.,Banach, D.,Borhani, D.W.,Burchat, A.,Dixon, R.W.,Marcotte, D.,Overmeyer, G.,Pivorunas, V.,Sadhukhan, R.,Sousa, S.,Moore, N.S.,Tomlinson, M.,Voss, J.,Wang, L.,Wishart, N.,Woller, K.,Talanian, R.V. Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor. Bmc Struct.Biol., 12:22-22, 2012 Cited by PubMed: 22995073DOI: 10.1186/1472-6807-12-22 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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