4E1Z
Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Non-receptor tyrosine-protein kinase TYK2 | polymer | 291 | 33696.5 | 1 | UniProt (Q9R117) Pfam (PF07714) | Mus musculus (mouse) | |
| 2 | B (A) | N-[5-(4-{[(3-chlorophenyl)sulfonyl]amino}phenyl)-1H-indazol-3-yl]furan-2-carboxamide | non-polymer | 492.9 | 1 | Chemie (0MX) | |||
| 3 | C (A) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A: 883 - 1173 (UniProt: Q9R117)
| PDB | External Database | Details |
|---|---|---|
| Ala 1019 | Asp 1016 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33696.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 492.9 | |
| All* | Total formula weight | 34189.5 |
