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4E1T

X-ray crystal structure of the transmembrane beta-domain from invasin from Yersinia pseudotuberculosis

4E1T の概要
エントリーDOI10.2210/pdb4e1t/pdb
関連するPDBエントリー4E1S
分子名称Invasin, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
機能のキーワードouter membrane beta barrel, adhesin, integrin, cell adhesion
由来する生物種Yersinia pseudotuberculosis
細胞内の位置Cell surface: P11922
タンパク質・核酸の鎖数1
化学式量合計32495.99
構造登録者
主引用文献Fairman, J.W.,Dautin, N.,Wojtowicz, D.,Liu, W.,Noinaj, N.,Barnard, T.J.,Udho, E.,Przytycka, T.M.,Cherezov, V.,Buchanan, S.K.
Crystal Structures of the Outer Membrane Domain of Intimin and Invasin from Enterohemorrhagic E. coli and Enteropathogenic Y. pseudotuberculosis.
Structure, 20:1233-1243, 2012
Cited by
PubMed Abstract: Intimins and invasins are virulence factors produced by pathogenic Gram-negative bacteria. They contain C-terminal extracellular passenger domains that are involved in adhesion to host cells and N-terminal β domains that are embedded in the outer membrane. Here, we identify the domain boundaries of an E. coli intimin β domain and use this information to solve its structure and the β domain structure of a Y. pseudotuberculosis invasin. Both β domain structures crystallized as monomers and reveal that the previous range of residues assigned to the β domain also includes a protease-resistant domain that is part of the passenger. Additionally, we identify 146 nonredundant representative members of the intimin/invasin family based on the boundaries of the highly conserved intimin and invasin β domains. We then use this set of sequences along with our structural data to find and map the evolutionarily constrained residues within the β domain.
PubMed: 22658748
DOI: 10.1016/j.str.2012.04.011
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.263 Å)
構造検証レポート
Validation report summary of 4e1t
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-04-09に公開中

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