4E0O

SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form III)

Summary for 4E0O

• Entry DOI: 10.2210/pdb4e0o/pdb
• Related: 4E0K 4E0L 4E0M 4E0N
• Descriptor: Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: amyloid, out-of-register, fiber-forming, macrocycle, protein fibril
• Total number of polymer chains: 4
• Total formula weight: 8840.21

Authors

Zhao, M.,Liu, C.,Sawaya, M.R.,Eisenberg, D. (deposition date: 2012-03-04, release date: 2012-12-19, Last modification date: 2023-11-15)

• Primary citation: Liu, C.,Zhao, M.,Jiang, L.,Cheng, P.N.,Park, J.,Sawaya, M.R.,Pensalfini, A.,Gou, D.,Berk, A.J.,Glabe, C.G.,Nowick, J.,Eisenberg, D.; Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates.; Proc.Natl.Acad.Sci.USA, 109:20913-20918, 2012; PubMed: 23213214; DOI: 10.1073/pnas.1218792109

Experimental method

X-RAY DIFFRACTION (1.82 Å)