4E0M
SVQIVYK segment from human Tau (305-311) displayed on 54-membered macrocycle scaffold (form I)
Summary for 4E0M
Entry DOI | 10.2210/pdb4e0m/pdb |
Related | 4E0K 4E0L 4E0N 4E0O |
Descriptor | Cyclic pseudo-peptide SVQIVYK(ORN)EF(HAO)(4BF)K(ORN), PHOSPHATE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total) |
Functional Keywords | amyloid, out-of-register, fiber-forming, macrocycle, protein fibril |
Total number of polymer chains | 4 |
Total formula weight | 8629.22 |
Authors | Zhao, M.,Liu, C.,Michael, S.R.,Eisenberg, D. (deposition date: 2012-03-04, release date: 2013-02-13, Last modification date: 2023-11-15) |
Primary citation | Liu, C.,Zhao, M.,Jiang, L.,Cheng, P.N.,Park, J.,Sawaya, M.R.,Pensalfini, A.,Gou, D.,Berk, A.J.,Glabe, C.G.,Nowick, J.,Eisenberg, D. Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates Proc.Natl.Acad.Sci.USA, 109:20913-20918, 2012 Cited by PubMed: 23213214DOI: 10.1073/pnas.1218792109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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