4DY8

Interactions of Mn2+ with a non-self-complementary Z-type DNA duplex

Summary for 4DY8

• Entry DOI: 10.2210/pdb4dy8/pdb
• Related: 4DWY
• Descriptor: DNA (5'-D(*CP*AP*CP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*GP*TP*G)-3'), DNA (5'-D(P*TP*G)-3'), ... (5 entities in total)
• Functional Keywords: z-type dna double helices, manganese ions, dna
• Total number of polymer chains: 4
• Total formula weight: 4851.24

Authors

Mandal, P.K.,Venkadesh, S.,Gautham, N. (deposition date: 2012-02-28, release date: 2012-11-28, Last modification date: 2024-03-20)

Primary citation

Mandal, P.K.,Venkadesh, S.,Gautham, N.
Interactions of Mn(2+) with a non-self-complementary Z-type DNA duplex
Acta Crystallogr.,Sect.F, 68:1420-1426, 2012

PubMed Abstract: Crystal structures of the hexanucleotide d(CACGCG)·d(CGCGTG) were determined in two crystal lattices when different concentrations of the counterion Mn2+ were used in crystallization. The availability of Mn2+ during the crystallization process appears to play an important role in inducing different crystal packings that lead to crystals belonging to the two space groups P2(1) and P6(5). Analysis of the molecular interactions of Mn2+ with the Z-form duplexes shows direct coordination to the purine residues G and A.

PubMed: 23192018
DOI: 10.1107/S1744309112041759

Experimental method

X-RAY DIFFRACTION (1.76 Å)