4DX6

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Summary for 4DX6

Entry DOI	10.2210/pdb4dx6/pdb
Related	4DX5 4DX7
Descriptor	Acriflavine resistance protein B, DARPIN, DODECYL-BETA-D-MALTOSIDE (3 entities in total)
Functional Keywords	darpin, multidrug efflux protein, membrane protein, transport protein
Biological source	Escherichia coli More
Cellular location	Cell inner membrane; Multi-pass membrane protein: P31224
Total number of polymer chains	5
Total formula weight	384589.44
Authors	Eicher, T.,Cha, H.,Seeger, M.A.,Brandstaetter, L.,El-Delik, J.,Bohnert, J.A.,Kern, W.V.,Verrey, F.,Gruetter, M.G.,Diederichs, K.,Pos, K.M. (deposition date: 2012-02-27, release date: 2012-05-02, Last modification date: 2024-02-28)
Primary citation	Eicher, T.,Cha, H.J.,Seeger, M.A.,Brandstatter, L.,El-Delik, J.,Bohnert, J.A.,Kern, W.V.,Verrey, F.,Grutter, M.G.,Diederichs, K.,Pos, K.M. Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop. Proc.Natl.Acad.Sci.USA, 109:5687-5692, 2012 Cited by PubMed: 22451937 DOI: 10.1073/pnas.1114944109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation