4DX6

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Acriflavine resistance protein B	polymer	1057	114793.3	3	UniProt (P31224) Pfam (PF00873) In PDB	Escherichia coli
2	D, E	DARPIN	polymer	169	18317.6	2		SYNTHETIC CONSTRUCT (ARTIFICIAL GENE)
3	A, B, C	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	7	Chemie (LMT)

Sequence modifications

A, B, C: 1 - 1049 (UniProt: P31224)

PDB	External Database	Details
Asn 616	Gly 616	conflict
Leu 1050	-	expression tag
Glu 1051	-	expression tag
His 1052	-	expression tag
His 1053	-	expression tag
His 1054	-	expression tag
His 1055	-	expression tag
His 1056	-	expression tag
His 1057	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	381015.1
Non-Polymers*	Number of molecules	7
	Total formula weight	3574.3
All*	Total formula weight	384589.4

*Water molecules are not included.