4DWY

Interactions of Mn2+ with a non-self-complementary Z-type DNA duplex

Summary for 4DWY

• Entry DOI: 10.2210/pdb4dwy/pdb
• Related: 3FQ5 3G2A 3ULM 3ULN 3ULO 3UM4 4DY8
• Descriptor: DNA (5'-D(*CP*AP*CP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*GP*TP*G)-3'), MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: z-type dna double helices, dna
• Biological source: synthetic construct; More
• Total number of polymer chains: 4
• Total formula weight: 7348.72

Authors

Mandal, P.K.,Venkadesh, S.,Gautham, N. (deposition date: 2012-02-27, release date: 2012-11-28, Last modification date: 2024-03-20)

Primary citation

Mandal, P.K.,Venkadesh, S.,Gautham, N.
Interactions of Mn(2+) with a non-self-complementary Z-type DNA duplex
Acta Crystallogr.,Sect.F, 68:1420-1426, 2012

PubMed Abstract: Crystal structures of the hexanucleotide d(CACGCG)·d(CGCGTG) were determined in two crystal lattices when different concentrations of the counterion Mn2+ were used in crystallization. The availability of Mn2+ during the crystallization process appears to play an important role in inducing different crystal packings that lead to crystals belonging to the two space groups P2(1) and P6(5). Analysis of the molecular interactions of Mn2+ with the Z-form duplexes shows direct coordination to the purine residues G and A.

PubMed: 23192018
DOI: 10.1107/S1744309112041759

Experimental method

X-RAY DIFFRACTION (1.61 Å)