4DWG
Crystal structure of Trypanosome cruzi farnesyl diphosphate synthase in complex with [2-(n-heptylamino)ethane-1,1-diyl]bisphosphonic acid and Mg2+
Summary for 4DWG
Entry DOI | 10.2210/pdb4dwg/pdb |
Related | 1YHK 1YHL 1YHM 3IBA 3ICK 3ICM 3ICN 3ICZ 4DWB 4DXJ |
Descriptor | Farnesyl pyrophosphate synthase, MAGNESIUM ION, [2-(heptylamino)ethane-1,1-diyl]bis(phosphonic acid), ... (8 entities in total) |
Functional Keywords | geranyl transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Trypanosoma cruzi |
Total number of polymer chains | 1 |
Total formula weight | 42100.80 |
Authors | Aripirala, S.,Amzel, L.M.,Gabelli, S.B. (deposition date: 2012-02-24, release date: 2013-01-16, Last modification date: 2023-09-13) |
Primary citation | Aripirala, S.,Szajnman, S.H.,Jakoncic, J.,Rodriguez, J.B.,Docampo, R.,Gabelli, S.B.,Amzel, L.M. Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. J.Med.Chem., 55:6445-6454, 2012 Cited by PubMed: 22715997DOI: 10.1021/jm300425y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.01 Å) |
Structure validation
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