4DW2

The crystal structure of uPA in complex with the Fab fragment of mAb-112

Summary for 4DW2

• Entry DOI: 10.2210/pdb4dw2/pdb
• Related: 4DVB
• Descriptor: Urokinase-type plasminogen activator, Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, ... (5 entities in total)
• Functional Keywords: urokinase-type plasminogen activator, antibody, serine protease, zymogen, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00749
• Total number of polymer chains: 3
• Total formula weight: 74301.45

Authors

Jiang, L.,Botkjaer, K.A.,Andersen, L.M.,Yuan, C.,Andreasen, P.A.,Huang, M. (deposition date: 2012-02-24, release date: 2013-01-16)

• Primary citation: Jiang, L.,Botkjaer, K.A.,Andersen, L.M.,Yuan, C.,Andreasen, P.A.,Huang, M.; Rezymogenation of active urokinase induced by an inhibitory antibody.; Biochem.J., 449:161-166, 2013; PubMed: 23016918; DOI: 10.1042/BJ20121132

Experimental method

X-RAY DIFFRACTION (2.97 Å)