4DTT
Crystal structure of human insulin degrading enzyme (ide) in complex with compund 41367
Summary for 4DTT
Entry DOI | 10.2210/pdb4dtt/pdb |
Related | 4DTV |
Descriptor | Insulin-degrading enzyme, ZINC ION, 2-[[2-[[(2S)-3-(3H-IMIDAZOL-4-YL)-1-METHOXY-1-OXO-PROPAN-2-YL]AMINO]-2-OXO-ETHYL]-(PHENYLMETHYL)AMINO]ETHANOIC ACID, ... (4 entities in total) |
Functional Keywords | metalloprotease, zinc binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14735 |
Total number of polymer chains | 2 |
Total formula weight | 230751.51 |
Authors | Guo, Q.,Deprez-Poulain, R.,Deprez, B.,Tang, W.J. (deposition date: 2012-02-21, release date: 2013-02-27, Last modification date: 2023-09-13) |
Primary citation | Charton, J.,Gauriot, M.,Guo, Q.,Hennuyer, N.,Marechal, X.,Dumont, J.,Hamdane, M.,Pottiez, V.,Landry, V.,Sperandio, O.,Flipo, M.,Buee, L.,Staels, B.,Leroux, F.,Tang, W.J.,Deprez, B.,Deprez-Poulain, R. Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-beta hydrolysis. Eur.J.Med.Chem., 79:184-193, 2014 Cited by PubMed: 24735644DOI: 10.1016/j.ejmech.2014.04.009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.22 Å) |
Structure validation
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