4DTG
Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
Summary for 4DTG
Entry DOI | 10.2210/pdb4dtg/pdb |
Related | 1ADZ 1TFX |
Descriptor | Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, light chain, Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, heavy chain, Tissue factor pathway inhibitor, ... (7 entities in total) |
Functional Keywords | antibody, inhibitor, blood coagulation, blood clotting inhibitor-immune system complex, blood clotting inhibitor/immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Isoform Alpha: Secreted. Isoform Beta: Microsome membrane ; Lipid-anchor, GPI-anchor : P10646 |
Total number of polymer chains | 3 |
Total formula weight | 57098.52 |
Authors | Svensson, L.A.,Breinholt, J.,Krogh, B.O.,Hilden, I. (deposition date: 2012-02-21, release date: 2012-06-13, Last modification date: 2023-09-13) |
Primary citation | Hilden, I.,Lauritzen, B.,Sorensen, B.B.,Clausen, J.T.,Jespersgaard, C.,Krogh, B.O.,Bowler, A.N.,Breinholt, J.,Gruhler, A.,Svensson, L.A.,Petersen, H.H.,Petersen, L.C.,Balling, K.W.,Hansen, L.,Hermit, M.B.,Egebjerg, T.,Friederichsen, B.,Ezban, M.,Bjorn, S.E. Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model. Blood, 119:5871-5878, 2012 Cited by PubMed: 22563084DOI: 10.1182/blood-2012-01-401620 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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