4DTG

Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model

Summary for 4DTG

• Entry DOI: 10.2210/pdb4dtg/pdb
• Related: 1ADZ 1TFX
• Descriptor: Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, light chain, Humanized recombinant FAB fragment, FAB 2021, of a murine antibody, heavy chain, Tissue factor pathway inhibitor, ... (7 entities in total)
• Functional Keywords: antibody, inhibitor, blood coagulation, blood clotting inhibitor-immune system complex, blood clotting inhibitor/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform Alpha: Secreted. Isoform Beta: Microsome membrane ; Lipid-anchor, GPI-anchor : P10646
• Total number of polymer chains: 3
• Total formula weight: 57098.52

Authors

Svensson, L.A.,Breinholt, J.,Krogh, B.O.,Hilden, I. (deposition date: 2012-02-21, release date: 2012-06-13, Last modification date: 2023-09-13)

• Primary citation: Hilden, I.,Lauritzen, B.,Sorensen, B.B.,Clausen, J.T.,Jespersgaard, C.,Krogh, B.O.,Bowler, A.N.,Breinholt, J.,Gruhler, A.,Svensson, L.A.,Petersen, H.H.,Petersen, L.C.,Balling, K.W.,Hansen, L.,Hermit, M.B.,Egebjerg, T.,Friederichsen, B.,Ezban, M.,Bjorn, S.E.; Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model.; Blood, 119:5871-5878, 2012; PubMed: 22563084; DOI: 10.1182/blood-2012-01-401620

Experimental method

X-RAY DIFFRACTION (1.8 Å)