4DT7
Crystal structure of thrombin bound to the activation domain QEDQVDPRLIDGKMTRRGDS of protein C
Summary for 4DT7
Entry DOI | 10.2210/pdb4dt7/pdb |
Related | 1SHH |
Descriptor | Thrombin light chain, Thrombin heavy chain, Vitamin K-dependent protein C, ... (7 entities in total) |
Functional Keywords | serine protease, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 6 |
Total formula weight | 71847.96 |
Authors | Pozzi, N.,Barranco-Medina, S.,Chen, Z.,Di Cera, E. (deposition date: 2012-02-20, release date: 2012-05-09, Last modification date: 2023-09-13) |
Primary citation | Pozzi, N.,Barranco-Medina, S.,Chen, Z.,Di Cera, E. Exposure of R169 controls protein C activation and autoactivation. Blood, 120:664-670, 2012 Cited by PubMed: 22535660DOI: 10.1182/blood-2012-03-415323 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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